The Cellular Scale Program aims to employ advanced machine learning-based protein design to create high-affinity binding probes that identify and target key regulators of mitophagy in Alzheimer’s. It also seeks to develop iPSC-generated models to understand the interplay between the cytoskeleton, mitochondria, and energy in Alzheimer’s. Additionally, the program supports a biotech start-up’s vision to address autophagy-driven degradation and correct mitophagy in Alzheimer’s. By exploring the novel role of ICL-tribute in the onset or spread of Alzheimer’s hallmarks, the program aims to gain new insights. Furthermore, it will investigate whether aging and deprivation of glucose and oxygen in mice replicate the mitochondrial dysfunction observed in Alzheimer’s.